Protein Labeling Reagents
Biotium NKX2.2(NX2/294), CF568 conjugate, 0.1mg/mL
Expression of NKX2.2 has been found in neuroendocrine tumors of the gut, making it a potential marker for the study of gastrointestinal neuroendocrine tumors. More recently, NKX2.2 protein was identified as a target of EWS-FLI-1, the fusion protein specific to Ewing sarcoma, and was shown to be differentially upregulated in Ewing sarcoma on the basis of array-based gene expression analysis. It acts as a valuable marker for Ewing sarcoma, with a sensitivity of 93% and a specificity of 89%, and aids in the differential diagnosis of small round cell tumors.Primary antibodies are available purified, or with a selection of fluorescent CF Dyes and other labels. CF Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF405S and CF405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.
Biotium FOXP3(FXP3/197), CF568 conjugate, 0.1mg/mL
Recognizes a protein of 47-55 kDa, which is identified as FOXP3. Its precise epitope is not known, but it has been mapped to the N-terminal portion of the protein. The FOX family of transcription factors is a large group of proteins that share a common DNA binding domain termed a winged-helix or forkhead domain. During early development, FOXP1 and FOXP2 are expressed abundantly in the lung, with lower levels of expression in neural, intestinal and cardiovascular tissues, where they act as transcription repressors. FOXP1 is widely expressed in adult tissues, while neoplastic cells often exhibit a dramatic change in expression level or localization of FOXP1. Mutations in FOXP3 gene cause IPEX, a fatal, X-linked inherited disorder characterized by immune dysregulation. The FOXP3 protein is essential for normal immune homeostasis. Specifically, FOXP3 represses transcription through a DNA binding forkhead domain, thereby regulating T cell activation.Primary antibodies are availabl
Medchemexpress LLC Mal-PEG10-NHS ester | 3055858-73-3 | 98.0% | 706.73 | 100 MG
Mal-PEG10-NHS ester is a PEG-based PROTAC linker designed for the synthesis of PROTACs. These molecules function by exploiting the intracellular ubiquitin-proteasome system to selectively degrade target proteins, connecting E3 ubiquitin ligase ligands with target protein ligands.
- PEG-based PROTAC linker
- Used in the synthesis of PROTACs
- Exploits the intracellular ubiquitin-proteasome system
- Selectively degrades target proteins
Biotium Human Transferrin, CF488A Conjugate, 1 mg
Transferrin is a glycoprotein that binds iron for delivery to vertebrate cells through receptor-mediated endocytosis. After binding to its receptor on the cell surface, transferrin is rapidly internalized by invagination of clathrin-coated pits with formation of endocytic vesicles, the acidic environment favors dissociation of iron from the transferrin-receptor complex. Following the release of iron, the apotransferrin is recycled to the plasma membrane where it is released from its receptor to scavenge more iron. Fluorescent conjugates of human transferrin can be used as tracers for investigation of endocytosis by microscopy. CF dyes are Biotium's line of next-generation fluorescent dyes with advantages in brightness, photostability, and conjugate specificity compared to other fluorescent dyes. Green fluorescent CF488A dye has excitation/emission at 490/515 nm.
![eMolecules 2042193-77-9 | BDP FL methyltetrazine | Broadpharm475.310 | C24H24BF2N7O | 95.000 | CC1=CC(C)=[N+]2C1=Cc1ccc(CCC(=O)NCc3ccc(cc3)-c3nnc(C)nn3)n1[B-]2(F)F | 5mg | 374905212](https://assets.fishersci.com/TFS-Assets/CCG/product-images/502513203.JPG-250.jpg)
eMolecules 2042193-77-9 | BDP FL methyltetrazine | Broadpharm475.310 | C24H24BF2N7O | 95.000 | CC1=CC(C)=[N+]2C1=Cc1ccc(CCC(=O)NCc3ccc(cc3)-c3nnc(C)nn3)n1[B-]2(F)F | 5mg | 374905212
BDP FL methyltetrazine | Broadpharm | 2042193-77-9475.310 | C24H24BF2N7O | 95.000 | CC1=CC(C)=[N+]2C1=Cc1ccc(CCC(=O)NCc3ccc(cc3)-c3nnc(C)nn3)n1[B-]2(F)F | 5mg | 374905212
eMolecules MB 543 NHS ester | Broadpharm |916.990 | C40H44N4O15S3 | 0.000 | CC1CC(C)(C)Nc2c1cc1C(c3ccc(cc3C(=O)N(C)CCS(O)(=O)=O)C(=O)ON3C(=O)CCC3=O)=c3cc4C(C)CC(C)(C)N=c4c(c3Oc1c2S(O)(=O)=O)S(O)(=O)=O | 1mg | 713699906
MB 543 NHS ester | Broadpharm |916.990 | C40H44N4O15S3 | 0.000 | CC1CC(C)(C)Nc2c1cc1C(c3ccc(cc3C(=O)N(C)CCS(O)(=O)=O)C(=O)ON3C(=O)CCC3=O)=c3cc4C(C)CC(C)(C)N=c4c(c3Oc1c2S(O)(=O)=O)S(O)(=O)=O | 1mg | 713699906
Biotium CD44 Standard(HCAM/918), CF488A conjugate, 0.1mg/mL
Recognizes a cell surface glycoprotein of 80-95 kDa (CD44) on lymphocytes, monocytes, and granulocytes (Leucocyte Typing Workshop V). Its epitope is resistant to digestion by trypsin and chymotrypsin. The CD44 family of glycoproteins exists in a number of variant isoforms, the most common being the standard 85-95 kDa or hematopoietic variant (CD44s). Higher molecular weight isoforms are described in epithelial cells (CD44v), which are believed to function in intercellular adhesion and stromal binding. CD44 immunostaining is commonly used for the discrimination of urothelial transitional cell carcinoma in-situ from non-neoplastic changes in the urothelium.Primary antibodies are available purified, or with a selection of fluorescent CF Dyes and other labels. CF Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF405S and CF405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescen
Biotium MALT-1(MT1/410), CF488A conjugate, 0.1mg/mL
Mucosa associated lymphoid tissue lymphoma translocation gene 1 (MALT1) is found in extranodal low-grade B cell lymphomas. MALT1 encodes two Ig-like C2-type domains and fuses with an API2 gene, which is highly expressed in adult lymphoid tissue. The translocation of this MALT1 gene, which maps to human chromosome 18q21, and the apoptosis-inhibiting API2 gene results in an increased development of MALT lymphomas and apoptosis inhibition. Sites at which this API2-MALT1 (11;18)(q21;q21) translocation commonly occurs are within human lung and kidney tissue. MALT lymphoma expresses nuclear Bcl10, which mediates the oligomerization and activation of a MALT1 caspase-like domain. MALT1 mRNA is found in pre-B cells, mature B cells and plasma cells.Primary antibodies are available purified, or with a selection of fluorescent CF Dyes and other labels. CF Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF405S and CF405M are not re
Medchemexpress LLC Luc Yellow CH dilithium | 67769-47-5 | 99.7% | 10 MG
Luc Yellow CH dilithium is a high-intensity fluorescent probe containing free hydrazyl groups. It can react with fatty aldehydes at room temperature and serves as a biological tracer to monitor neuronal branching, regeneration, gap junction detection and characterization, and selective ablation of cells after aldehyde fixation. Luc Yellow CH displays the maximum excitation/emission of 430 nm/540 nm, respectively.
- Fluorescent dye
- Biological tracer to monitor neuronal branching, regeneration, gap junction detection and characterization, and selective ablation of cells after aldehyde fixation
- Cell imaging/staining
- Used for Lucifer yellow CH (10 μg/mL; 12 h) staining images
- Used to evaluate GJ functionality
eMolecules 477876-64-5 | BP Fluor 532 NHS Ester | Broadpharm723.770 | C34H33N3O11S2 | 0.000 | CC1Nc2c(cc3C(c4ccc(cc4)C(=O)ON4C(=O)CCC4=O)=c4cc5c(=NC(C)C5(C)C)c(c4Oc3c2S(O)(=O)=O)S(O)(=O)=O)C1(C)C | 1mg | 599128630
BP Fluor 532 NHS Ester | Broadpharm | 477876-64-5723.770 | C34H33N3O11S2 | 0.000 | CC1Nc2c(cc3C(c4ccc(cc4)C(=O)ON4C(=O)CCC4=O)=c4cc5c(=NC(C)C5(C)C)c(c4Oc3c2S(O)(=O)=O)S(O)(=O)=O)C1(C)C | 1mg | 599128630
STEMCELL Technologies GloCell™ Fixable Viability Dye UV 450, Size: 500 Tests
GloCell™ Fixable Viability Dye UV 450 is a fluorescent cell viability dye for staining live/dead mammalian cells in applications such as flow cytometry. The dye irreversibly binds intracellular and cell surface amine groups and can be utilized prior to fixation, permeabilization, or cryopreservation. Cells with compromised plasma membranes become permeable to the GloCell™ dye, resulting in a greater fluorescence compared to live cells in a cell viability assay.GloCell™ Fixable Viability Dye UV 450 is excited by the UV laser at 355 nm and it has a fluorescence emission maximum of 450 nm that can be detected using the 450/50 band pass filter used to detect DAPI, Hoechst 33258, etc.
Biotium Estrogen Receptor(ESR1/420), CF568 conjugate, 0.1mg/mL
This MAb is specific to ER alpha and shows minimal cross-reaction with other members of the family. Epitope of this MAb is mapped between aa300-550. ER is an important regulator of growth and differentiation in the mammary gland. Presence of ER in breast tumors indicates an increased likelihood of response to anti-estrogen (e.g. tamoxifen) therapy.Primary antibodies are available purified, or with a selection of fluorescent CF Dyes and other labels. CF Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF405S and CF405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.
Cytoskeleton, Inc. SiR700-Actin Kit
Composed of: 35 nmol SiR700-Actin and 1 µmol verapamil. SiR700-actin is based on the far-red silicon rhodamine (SiR) fluorophore analogue SiR700 and the actin binding natural product jasplakinolide. SiR700-actin allows labeling of endogenous F-actin in live cells with high specificity and low background without the need for genetic manipulation or over-expression. The key features of SiR700-actin are i) far-red absorption and emission wavelengths, ii) cell permeability, iii) fluorogenic character, and iv) compatibility with super-resolution microscopy (e.g., STED & SIM). In addition, SiR700 actin can be used for wide-field and confocal fluorescent imaging in living cells. The emission in the far-red wavelength minimizes phototoxicity and sample autofluorescence. SiR700-actin is compatible with GFP and/or m-cherry fluorescent proteins.
Cayman Chemical 17a 20DIhydroxy4pregn3 10mg
An endogenous, maturation-inducing steroid that at 1 UG/ml induces germinal vesicle breakdown in oocytes from several teleost species; can also influence spermiation by stimulating milt production when administered at 5 mg/kg to various male teleosts
American Research Products Inc Mouse Protein disulfide isomer
Mouse Protein disulfide-isomerase A4 (PDIA4) ELISA kit from CUSABIO Detection Range 0 312 ng/mL-20 ng/mL Sensitivity 0 078 ng/mL Sample serum plasma tissue homogenates cell lysates Method Sandwich